Reference Library

Please note, we have put together an extensive Reference Library for you and therefore there are many documents and reading material in this section, for both Medics and the general public.  Please ensure you scroll all the way down the page, and do contact us if you would like anything clarified, or further information emailed to you.

 

articleslant

Published sports article on Empower NeuroSport and Sport Recovery Max article-sports

Click here to see some of the diseases which are linked to insufficient levels of glutathione.

DOCUMENT FOR PRACTITIONERS / MEDICS :  GLUTACYAN DOUBLE BLIND CLINICAL TRIAL – 98% BIOAVAILABILITY  GLUTACYAN DOUBLE BLIND CLINICAL TRIAL (formerly RECANCOSTAT)

DOCUMENT FOR PRACTITIONERS / MEDICS :      STUDY – REDUCED GLUTATHIONE & ANTHOCYANS  — Redox cycling and redox recycling in biological systems Praxis-Telegram

Praxis-Telegram-file

DOCUMENT FOR PRACTITIONERS / MEDICS :   European Journal of Cancer Volume 33 issue supp-S8 – Preliminary study of GSH L-Cysteine Anthocyane (Recancostat Comp (1) copy 2  

DOCUMENT FOR PRACTITIONERS / MEDICS :  –  BIOGRAPHY – PROFESSOR TREUSCH  FOUNDER OF EMPOWER GLUTACYAN/RECANCOSTAT AND ITS UNIQUE DELIVERY SYSTEM

DOCUMENTS FOR PRACTITIONERS / MEDICS :   MEDICAL ARTICLE ON GLUTACYAN (FORMERLY RECANCOSTAT) BY DR J DEBE.  http://empowerhealthuk.com/our-products/glutacyan/premier-supplement-21st-century/

WHITE PAPER FOR PRACTITIONERS / MEDICS :   –  Glutathione As A Novel Therapeutic Approach by Dr Michael Culp, regarding Empower glutathione supplements

Link to the Brazilian Distributor of Glutacyan’s website www.glutathion-portal.com

Please scroll further down this page for further numerous  clinical Reference papers and studies

‘GLUTATHIONE – ANTI-AGING AND THE FOUNTAIN OF YOUTH’   ezine article by Adrian Goad


DIAGRAM – Formation of Free Radicals by Dr Gabriel Devriendt

Diagram - Formation of Free Radicals by Dr. Gabriel Devriendt.

Diagram – Formation of Free Radicals by Dr Gabriel Devriendt

 

 

 

 

 

 

 

 

“Glutathione:  The Great Protector” –  magazine Article

GLUTATHIONE DESCRIPTION PAPER

Anthocyanins and their role in cancer prevention NIH

Glutathione IV paper

Central European Journal of IMMUNOLOGY

41WQDqMIwOL._BO2,204,203,200_PIsitb-sticker-arrow-click,TopRight,35,-76_SX385_SY500_CR,0,0,385,500_SH20_OU02_

Integrative Oncology details RAYGEL

EXCERPT FROM INTEGRATIVE ONCOLOGY BOOK REGARDING RAYGEL (page 142)

“RayGel TM is a topical gel consisting of anthocyanins and glutathione.  A small clinical study by Noel Peterson, ND showing prevention of radiotherapy related skin burning was presented at the 2004 annual meeting of the American Association of Naturopathic Physicians (Miko Enomoto, et al;, 2005).  Aloe has not been shown to be effective.  Aloe vera is widely prescribed and used for radiation burns but one controlled clinical trial reported that aloe vera gel did not significantly reduce radiation-induced skin side effects (Heggie, et al., 2002)”.

RAYGEL CLINICAL TRIAL AND RESULTS

RAYGEL – LEGACY CANCER SERVICES ACTIVE STUDY   Pages 26 & 27

RAYGEL LEGACY CANCER SERVICES  (Complete Brochure – Please refer to pages 26 & 27 for RayGel Study)

EMPOWER GLUTATHIONE DEPLETION CHART  How Glutathione is depleted in our bodies.

Glutacyan Diagram

GLUTATHIONE HOME PAGE

Nicky Elsworth Newspaper Article

Riolife Eye – Nightblindness STUDY – Influence on nutrients and habits

glutathione depletion chart

METHYLATION & TRANSSULFURATION PATHWAYS :GLUTATHIONE - DIAGRAM

 

 

 

 

 

 

 

http://www.ncbi.nlm.nih.gov/pubmed/23942595

 

PUBLISHED PAPERS & TRIALS –  Professor Gernot Treusch (founder of Glutacyan and Empower Products)

(Please note – ‘RECANCOSTAT’ is now called GLUTACYAN & SPORT RECOVERY MAX)

GLUTACYAN & SPORT RECOVERY MAX CLINICAL TRIALS/STUDIES

1.  Up-regulation of interferon-gamma production by reduced glutathione, anthocyane and L-cysteine treatment in children with allergic asthma and recurrent respiratory diseases.

Negative correlation between serum IgE levels and production of IFN-gamma by lymphocytes and positive correlation between serum IgE levels and production of IL-4 by lymphocytes was detected in 12 children with allergic asthma and recurrent respiratory diseases. Deficiency of reduced glutathione in whole blood and some disorders in phagocytic and oxidative burst activity of monocytes were observed in these children. Use of reduced glutathione, L-cysteine and anthocyane (Rec., Clear Vision, Switzerland) resulted in elevation of IFN-gamma production, lymphocyte response to mitogens, NK cell activity, increase in percentage of naive CD4(+) T lymphocytes (refreshment effect) and improvement of clinical status. Positive clinical results lasted 6 months.
 Source: Chernyshov VP, Omelchenko LI, Treusch G, et al. Russ J Immunol. 2002 Apr;7(1):48-56.

2.  Effects of Rec. Comp. on immune system on Chernobyl children with RRD.

Rec. Comp. (RC – tablets of reduced glutathione, l-cysteine, and anthyocane) were used in the treatment of children (8-14 years old) with recurrent respiratory diseases (RRD). Children lived on the territory with contamination of radionuclides after Chernobyl accident. Before treatment levels of absolute number of CD3/CD4 lymphocytes, PHA-lymphocyte response, and activity of phagocytosis were decreased. Levels of spontaneous NBT-test of blood neutrophils (without ex vivo stimulation) were high. After RC treatment significant elevation to normal ranges of numbers of CD3/CD4-lymphocytes, levels of PHA-stimulated lymphocyte response and activity of phagocytosis were detected. Immediately after treatment, levels of stimulated NBT-test were extremely low. But 5 months investigation confirmed positive effect of RC: normal levels of spontaneous and stimulated NBT-test and good levels of reserve were investigated. In temporary low levels of stimulated NBT-test immediately after treatment we suppose the mechanism of reduced glutathione metabolism to react with free radicals. Positive immunological dynamics correlated with good clinical effects.
Source: Chernyshov VP, Omelchenko LI, Treusch G, et al.  Int J Immunorehabilitation.  May 1997;5:72.


3.  Preliminary study of GSH L-cysteine anthocyane (Rec. Comp) in metastatic colorectal carcinoma with relative denutrition.

 Reduced glutathione (GSH) is a sulphur-containing nucleophile natural metabolic molecule able to maintain cellular integrity and protect healthy cells against toxic and radicalic compounds at physiological doses. Administered orally at high doses GSH associated with both L-Cysteine Glutathione precursor and Anthocyane (Rec Comp). The drug had been reported concerning a chemoprotection against tissue toxicity of cytotoxic agents and multi-drug resistance. Also the drug may induce inhibition of tumor growth in vitro and tumor regression with recovered nutrition and weight in vivo (on rats).  A clinical trial had conducted in eleven (first group of multi-step Fleming evaluation test) metastatic colorectal carcinomachemoresistant patients with various denutrition phase and loss of weight. We report first clinical data for this study. Treatment consisted in oral administration of 800 mg GSH twice a day for a minimum of 90 days or until progression or toxicity (total dose: 144g GSH, 28.8 g L-cysteine, 23 g. Anthocyane). No drug related toxicities observed. Eight patients were evaluated. All patients (8) are living (3-10 months) and the median duration of treatment was 21 weeks (11-33). Four patients recovered normal diet, high Karnowsky and increased weight (three were able to return home), four patients had no response.

Conclusion: In addition of active therapeutic effect in cancer and chemoprotection, Rec. Comp. maintains Karnowsky, nutrition, and weight of multi-treated patients. Because no toxicity with Rec. Comp. at high doses, we will select patients with cancer cachexia in second step of extended trial.
SourceGarcia-Giralt E, Pedereau B, Brixy F, et al. Presented at the European Cancer Conference. September 14-18, 1997. Eur J Cancer. 1997:33(sup 8).

 4.  Immunological analysis of reduced glutathione, L-cysteine and anthocyane effects in Chernobyl children with recurrent respiratory infections and chronic inflammatory focal lesions.

Deficiency in glutathione system: decreased levels of reduced glutathione (GSH) in plasma, whole blood; elevated intracellular levels of GSH in lymphocytes, and especially in monocytes, were detected in 12 Chernobyl children with recurrent respiratory infections (RRI) and chronic inflammatory focal lesions (CIFL group) in comparison with 6 Chernobyl children with RRI only (placebo-controlled group) living in the same territory contaminated by radionuclides.  Deficiency in cytokine release (TNF, IL-10, IL-12) by monocytes, in phagocytic function of neutrophils and monocytes and disorders in oxidative burst activity of neutrophils and monocytes; as some disorders in lymphocyte subsets were detected in CIFL children in comparison to placebo-control group.  Use of reduced glutathione, L-cysteine and anthocyane (Rec. Comp., Clear Vision, Switzerland) resulted in normalization of immune status, glutathione balance (blood plasma and intracellular levels of GSH), and improvement in clinical status.  Frequency of acute RRI per year decreased by 5.8 times in CIFL group of children and by 2 times in placebo control group.

Source: Chernyshov VP, Omelchenko LI, Treusch G, et al.  Cent Euro J Immunol. 2000;25(3):137-145.


5.  Disorders in mononuclear phagocytes and reduced glutathione and their correction in Chernobyl children with recurrent respiratory infections and chronic inflammatory focal lesions.

Deficiency in glutathione system revealed by decreased levels of reduced glutathione (GSH) in blood plasma and in whole blood and elevated intracellular levels of GSH in lymphocytes and especially in mononuclear phagocytes were detected in 12 Chernobyl children with recurrent respiratory infections (RRI) and chronic inflammatory focal lesions: chronic bronchitis, gastroduodenitis, maxilla sinusitis, and gastroesophageal reflux, (CIFL group of children) in comparison with six Chernobyl children with RRI only – placebo-control (PC) group, living in the same territory contaminated by radionuclides.  Deficiency of TNF, IL-10, IL-12 release after LPS stimulation of mononuclear phagocytes were detected in CIFL group.  Disorders in oxidative burst activity of mononuclear phagocytes neutrophils were observed.  Therapy by GSH, L-cysteine and anthocyane resulted normalization (reconstitution_ of mononuclear phagocytes and neutrophils function, glutathione balance (blood plasma and intracellular levels of GSH) and improvement in clinical status.  Elevated levels of lymphocyte subsets CD3+CD8+CD38+, CD3+CD8+CD57+, CD19+CD5+ in CIFL group decreased and reached levels of PC group.  Proliferative response of T-lymphocytes to anti-CD3 mAb increased after therapy.  Frequency of acute RRI per year decreased by 5.8 times after therapy in CIFL group and by 2 times in PC group of children.
Source: Chernyshov VP, Omelchenko LI, Treusch G, et al.  Abstracts of the 14th European Immunology Meeting EFIS.  September 23-27 2000.  EFIS.  2000:73(2,3) :75-302.

 6.  Refreshment effect of reduced glutathione, anthocyans and L-cysteine on lymphocyte subsets and prevention of respiratory infections in Chernobyl children.

Objective: Analysis of immune mechanisms in prevention of recurrent respiratory infections in children by Rec. Comp. treatment (tablets of reduced glutathione, anthocyans and L-cysteine).
Method and Populations: IMK-lymphocyte and CD28 monoclonal antibodies were used for two-color flow-cytometry.  NK-cell activity, PHA and PWM proliferative response, anti-thyroid antibodies, thyroid hormones and IgE were studied before, after and 5 months after Rec. Comp. treatment in 11 Chernobyl children with recurrent respiratory infections living on contaminated by radionuclides territory (5-15 Ci/km^2).
Results: Increase of CD28+/CD8+ lymphocyte levels, normalization of low NK-cell activity and PHA-proliferative response and decrease of high IgE levels, normalization of high levels of absolute counts and percentage of activate T-lymphocytes bearing HLA DR marker (CD3+/HLA DR+) especially in more heavy cases and complicated with anti-thyroid antibodies were detected after Rec. Comp. treatment.  There was positive clinical effect during 5 months after treatment.
Conclusion: Reduced glutathione, anthocyans, and L-cysteine in combined using have refreshment effect on lymphocyte subsets that prevent respiratory infections in immunocompromized Chernobyl children.
Source: Chernyshov VP, Omelchenko LI, Treusch G, et al.  Programs and Abstracts of the 5th International Conference on the Prevention of Infection.  May 6-7, 1998.  NICE.  1998.

7.  Disorders in GSH, phagocytosis and monocyte production of TNF, IL-10, IL-12 in children with RRD complicated by allergy and chronic inflammatory focal lesions. 

Deficiency of reduced glutathione (GSH) in whole blood of children with recurrent respiratory disorders (RRD) complicated by allergy (A) and chronic inflammatory focal lesions (CIFL) was detected.  RRD patients without complications were as placebo-control group (PC).  42 Chernobyl children living on territory contaminated by radionuclides were included into study.  Elevated percentage of phagocytosis but decreased phagocytosis intensity in neutrophils and monocytes were detected in A and CIFL patients.  In CIFL but not in A patients percentage of neutrophils with oxidative burst activity after stimulation by fMLP and E.coli was elevated but intensity of oxidative burst was elevated in both groups.  Deficiency of release of TNF, IL-10, IL-13 by monocytes was detected in A and CIFL patients.  Therapy by Rec. Comp. (GSH, L-cysteine, anthocyane) resulted normalization in phagocytosis and intracellular ingesting of neutrophils and monocytes, GSH balance and improvement in clinical status.  In CIFL children cytokine production was normalised.  Positive clinical effect of therapy in A group during 0.5 year and in CIFL group during one year was registered.
Source: Chernyshov VP, Omelchenko LI, Treusch G, et al.  Abstracts of the 14th International Congress of Immunology.  July 24, 2001.  Scandinavian J Immunol.  July/August 2001:54(Supp. 1).


8. An alternative for skin care during external radiation beam radiation.

Objective: Skin reaction during radiation therapy for breast malignancy can result in significant discomfort and desquamation which may necessitate delays in therapy. Rreduced glutathione (GSH) and anthocyanins are natural antioxidants with transdermal absorption noted to dramatically decrease the observed skin reaction during radiotherapy (XRT) in a few patients treated in our department. This spurred us to undertake an objective evaluation of their effectiveness.

 Methods: Patients undergoing whole breast external beam irradiation were randomised to receive either placebo or GSH/anthyyanins one to three hours before daily therapy over their 6 weeks course of treatment. Standard skin care of Vitamin E oil and Aloe Vera was used in both groups. Patients and investigators/staff were blinded. Skin reaction was documented by photographs and a severity scale.
Results: Thirty two (32) patients were enrolled. Thirty (30) were evaluable. Fifteen (15) received placebo, 15 GSH/anthocyanins. Scores were calculated by percent of breast skin involved and grade of reaction. The group receiving GSH/anthocyanins had a lower average score, 93.67 vs the placebo groups 123.33. This translated to an average severity score in the GSH/anthocyanins group 24% less than that seen in the placebo group. Small group numbers for the pilot trial did not reach statistical significance (p > .05), but showed a trend in favor of GSH/anthocyanins.
Conclusion: GSH/anthocyanins can provide skin protection during XRT which supercedes that observed with standard skin care and placebo. This formula may reduce discomfort associated with breast irradiation.
SourceEnomoto TM, Johnson T, Petersen N, Homer L, Walts D, Johnson N. Presented at the Portland Surgical Society Annual Scientific Meeting (2003) and the North Pacific Surgical Association Annual Meeting (2004) .

1.  Up-regulation of interferon-gamma production by reduced glutathione, anthocyane and L-cysteine treatment in children with allergic asthma and recurrent respiratory diseases.Negative correlation between serum IgE levels and production of IFN-gamma by lymphocytes and positive correlation between serum IgE levels and production of IL-4 by lymphocytes was detected in 12 children with allergic asthma and recurrent respiratory diseases. Deficiency of reduced glutathione in whole blood and some disorders in phagocytic and oxidative burst activity of monocytes were observed in these children. Use of reduced glutathione, L-cysteine and anthocyane (Rec., Clear Vision, Switzerland) resulted in elevation of IFN-gamma production, lymphocyte response to mitogens, NK cell activity, increase in percentage of naive CD4(+) T lymphocytes (refreshment effect) and improvement of clinical status. Positive clinical results lasted 6 months.Source: Chernyshov VP, Omelchenko LI, Treusch G, et al. Russ J Immunol. 2002 Apr;7(1):48-56.2.  Effects of Rec. Comp. on immune system on Chernobyl children with RRD.Rec. Comp. (RC – tablets of reduced glutathione, l-cysteine, and anthyocane) were used in the treatment of children (8-14 years old) with recurrent respiratory diseases (RRD). Children lived on the territory with contamination of radionuclides after Chernobyl accident. Before treatment levels of absolute number of CD3/CD4 lymphocytes, PHA-lymphocyte response, and activity of phagocytosis were decreased. Levels of spontaneous NBT-test of blood neutrophils (without ex vivo stimulation) were high. After RC treatment significant elevation to normal ranges of numbers of CD3/CD4-lymphocytes, levels of PHA-stimulated lymphocyte response and activity of phagocytosis were detected. Immediately after treatment, levels of stimulated NBT-test were extremely low. But 5 months investigation confirmed positive effect of RC: normal levels of spontaneous and stimulated NBT-test and good levels of reserve were investigated. In temporary low levels of stimulated NBT-test immediately after treatment we suppose the mechanism of reduced glutathione metabolism to react with free radicals. Positive immunological dynamics correlated with good clinical effects.Source: Chernyshov VP, Omelchenko LI, Treusch G, et al.  Int J Immunorehabilitation.  May 1997;5:72. 3.  Preliminary study of GSH L-cysteine anthocyane (Rec. Comp) in metastatic colorectal carcinoma with relative denutrition.Reduced glutathione (GSH) is a sulphur-containing nucleophile natural metabolic molecule able to maintain cellular integrity and protect healthy cells against toxic and radicalic compounds at physiological doses. Administered orally at high doses GSH associated with both L-Cysteine Glutathione precursor and Anthocyane (Rec Comp). The drug had been reported concerning a chemoprotection against tissue toxicity of cytotoxic agents and multi-drug resistance. Also the drug may induce inhibition of tumor growth in vitro and tumor regression with recovered nutrition and weight in vivo (on rats).A clinical trial had conducted in eleven (first group of multi-step Fleming evaluation test) metastatic colorectal carcinomachemoresistant patients with various denutrition phase and loss of weight. We report first clinical data for this study. Treatment consisted in oral administration of 800 mg GSH twice a day for a minimum of 90 days or until progression or toxicity (total dose: 144g GSH, 28.8 g L-cysteine, 23 g. Anthocyane). No drug related toxicities observed. Eight patients were evaluated. All patients (8) are living (3-10 months) and the median duration of treatment was 21 weeks (11-33). Four patients recovered normal diet, high Karnowsky and increased weight (three were able to return home), four patients had no response.Conclusion: In addition of active therapeutic effect in cancer and chemoprotection, Rec. Comp. maintains Karnowsky, nutrition, and weight of multi-treated patients. Because no toxicity with Rec. Comp. at high doses, we will select patients with cancer cachexia in second step of extended trial.Source: Garcia-Giralt E, Pedereau B, Brixy F, et al. Presented at the European Cancer Conference. September 14-18, 1997. Eur J Cancer. 1997:33(sup 8). 4.  Immunological analysis of reduced glutathione, L-cysteine and anthocyane effects in Chernobyl children with recurrent respiratory infections and chronic inflammatory focal lesions.Deficiency in glutathione system: decreased levels of reduced glutathione (GSH) in plasma, whole blood; elevated intracellular levels of GSH in lymphocytes, and especially in monocytes, were detected in 12 Chernobyl children with recurrent respiratory infections (RRI) and chronic inflammatory focal lesions (CIFL group) in comparison with 6 Chernobyl children with RRI only (placebo-controlled group) living in the same territory contaminated by radionuclides.  Deficiency in cytokine release (TNF, IL-10, IL-12) by monocytes, in phagocytic function of neutrophils and monocytes and disorders in oxidative burst activity of neutrophils and monocytes; as some disorders in lymphocyte subsets were detected in CIFL children in comparison to placebo-control group.  Use of reduced glutathione, L-cysteine and anthocyane (Rec. Comp., Clear Vision, Switzerland) resulted in normalization of immune status, glutathione balance (blood plasma and intracellular levels of GSH), and improvement in clinical status.  Frequency of acute RRI per year decreased by 5.8 times in CIFL group of children and by 2 times in placebo control group.

Source: Chernyshov VP, Omelchenko LI, Treusch G, et al.  Cent Euro J Immunol. 2000;25(3):137-145.

 

5.  Disorders in mononuclear phagocytes and reduced glutathione and their correction in Chernobyl children with recurrent respiratory infections and chronic inflammatory focal lesions.

Deficiency in glutathione system revealed by decreased levels of reduced glutathione (GSH) in blood plasma and in whole blood and elevated intracellular levels of GSH in lymphocytes and especially in mononuclear phagocytes were detected in 12 Chernobyl children with recurrent respiratory infections (RRI) and chronic inflammatory focal lesions: chronic bronchitis, gastroduodenitis, maxilla sinusitis, and gastroesophageal reflux, (CIFL group of children) in comparison with six Chernobyl children with RRI only – placebo-control (PC) group, living in the same territory contaminated by radionuclides.  Deficiency of TNF, IL-10, IL-12 release after LPS stimulation of mononuclear phagocytes were detected in CIFL group.  Disorders in oxidative burst activity of mononuclear phagocytes neutrophils were observed.  Therapy by GSH, L-cysteine and anthocyane resulted normalization (reconstitution_ of mononuclear phagocytes and neutrophils function, glutathione balance (blood plasma and intracellular levels of GSH) and improvement in clinical status.  Elevated levels of lymphocyte subsets CD3+CD8+CD38+, CD3+CD8+CD57+, CD19+CD5+ in CIFL group decreased and reached levels of PC group.  Proliferative response of T-lymphocytes to anti-CD3 mAb increased after therapy.  Frequency of acute RRI per year decreased by 5.8 times after therapy in CIFL group and by 2 times in PC group of children.

Source: Chernyshov VP, Omelchenko LI, Treusch G, et al.  Abstracts of the 14th European Immunology Meeting EFIS.  September 23-27 2000.  EFIS.  2000:73(2,3) :75-302. 

6.  Refreshment effect of reduced glutathione, anthocyans and L-cysteine on lymphocyte subsets and prevention of respiratory infections in Chernobyl children.

Objective: Analysis of immune mechanisms in prevention of recurrent respiratory infections in children by Rec. Comp. treatment (tablets of reduced glutathione, anthocyans and L-cysteine).

Method and Populations: IMK-lymphocyte and CD28 monoclonal antibodies were used for two-color flow-cytometry.  NK-cell activity, PHA and PWM proliferative response, anti-thyroid antibodies, thyroid hormones and IgE were studied before, after and 5 months after Rec. Comp. treatment in 11 Chernobyl children with recurrent respiratory infections living on contaminated by radionuclides territory (5-15 Ci/km^2).

Results: Increase of CD28+/CD8+ lymphocyte levels, normalization of low NK-cell activity and PHA-proliferative response and decrease of high IgE levels, normalization of high levels of absolute counts and percentage of activate T-lymphocytes bearing HLA DR marker (CD3+/HLA DR+) especially in more heavy cases and complicated with anti-thyroid antibodies were detected after Rec. Comp. treatment.  There was positive clinical effect during 5 months after treatment.

Conclusion: Reduced glutathione, anthocyans, and L-cysteine in combined using have refreshment effect on lymphocyte subsets that prevent respiratory infections in immunocompromized Chernobyl children.

Source:Chernyshov VP, Omelchenko LI, Treusch G, et alPrograms and Abstracts of the 5th International Conference on the Prevention of Infection.  May 6-7, 1998.  NICE.  1998.

 7.  Disorders in GSH, phagocytosis and monocyte production of TNF, IL-10, IL-12 in children with RRD complicated by allergy and chronic inflammatory focal lesions. 

Deficiency of reduced glutathione (GSH) in whole blood of children with recurrent respiratory disorders (RRD) complicated by allergy (A) and chronic inflammatory focal lesions (CIFL) was detected.  RRD patients without complications were as placebo-control group (PC).  42 Chernobyl children living on territory contaminated by radionuclides were included into study.  Elevated percentage of phagocytosis but decreased phagocytosis intensity in neutrophils and monocytes were detected in A and CIFL patients.  In CIFL but not in A patients percentage of neutrophils with oxidative burst activity after stimulation by fMLP and E.coli was elevated but intensity of oxidative burst was elevated in both groups.  Deficiency of release of TNF, IL-10, IL-13 by monocytes was detected in A and CIFL patients.  Therapy by Rec. Comp. (GSH, L-cysteine, anthocyane) resulted normalization in phagocytosis and intracellular ingesting of neutrophils and monocytes, GSH balance and improvement in clinical status.  In CIFL children cytokine production was normalized.  Positive clinical effect of therapy in A group during 0.5 year and in CIFL group during one year was registered.

Source: Chernyshov VP, Omelchenko LI, Treusch G, et al.  Abstracts of the 14th International Congress of Immunology.  July 24, 2001.  Scandinavian J Immunol.  July/August 2001:54(Supp.

 

1.         The role of glutathione in combination with cisplatin in the treatment of ovarian cancer, Tedeschi, M; De Cesare, A.; Oriania, S.; Perego, P.; Silva, A.; Venturino, P.; Zunino, F.; Cancer Treatment Reviews (1991) 18, 253-2592.         Reduced Glutathione Protects against Cisplatin-induced Neurotoxicity in Rats, Hamers, F.P.T.; Brakkee, J.H.; Cavalletti, E.; Tedeschi, M.; Marmonti, L.; Pezzoni, G.; Neijt, J.P.; Gipsen, W.H.; Cancer Research 53, 544-549, February 1, (1993)3.         Protective effect of reduced glutathione against cisplatin induced renal and systemic toxicity and its influence on the therapeutic activity of antitumor drug, Zunino, F.; Pratesi, G.; Micheloni, A.; Cavalletti, E.; Sala, F.; Tofanetti, O.; Chem.-Biol. Interactions, 70 (1989) 89-101, Elsevier Scientific Publishers Ireland Ltd.4.         Prevention of cyclophosphamide-induced urotoxicity by reduced glutathione and its effect on acute toxicity and antitumor activity of the alkylating agent, Tofanetti, O.; Cavalletti, E.; Besati, A.; Pratesi, G.; Pezzoni, G.; Zunino, F.; Cancer Chemother. Pharmacol. (1985) 14: 188-1935.         Prevention of Doxorubicin Myocardial Toxicity in Mice by Reduced Glutathione, Yoda, Y.; Nakazawa, M.; Abe, T.; Kawakami, Z.; Cancer Research 46, 2551-2556, May (1986)6.         Influence of glutathione administration on the disposition of free and total platinum in patients after administration of cisplatin, Leone, R.; Fracasso, M.E.; Soresi, E.; Cimino, G.; Tedeschi, M.; Castoldi, D.; Monzani, V.; Colombi, L.; Usari, T.; Bernareggi, A.; Cancer Chemother. Pharmacol. (1992) 29: 385-3907.         Phase I Trial of Cisplatin in Combination with Glutathion, Plaxe, St.; Freddo, J.; Kim, S.; Kirmani, S.; McClay, E.; Christen, R.; Braly, P.; Howell, St.; Gynecology Oncology 55, 82-86 (1994)8.         Weekly 5-fluorouracil and folinic acid plus escalating doses of cisplatin with glutathione protection in patients with advanced head and neck cancer, Gebbia, V.; Valenza, R.; Testa, A.; Zerillo, G.; Restivo, S.; Cupido, G.; Ingria, F.; Spadafora, F.; Barbaccia, C.; Cannata, G.; Cipolla, C.; Gebbia, N.; Med. Oncol. & Pharmacother. Vol. 9 No. 4 pp. 165-168, (1992)9.         A phase II study of combination chemotherapy in advanced ovarian carcinoma with cisplatin and cyclophosphamide plus reduced glutathione as potential protective agent against cisplatin toxicity, Locatelli, M.C.;D´Antona, A.; Labianca, R.; Vinci, M.; Tedeschi, M.; Carcione, R.; Corbo, A.; Venturino, P.; Luporini, G.; Tumori, 79: 37-39 (1993)10.       Efficacy and safety of high-dose cisplatin and cyclophosphamide with glutathione protection in the treatment of bulky advanced epithelial ovarian cancer, Di Re, F.; Bohm, S.; Oriana, S.; Spatti, G.B.; Zunino, F.; Cancer Chemother. Pharmacol. (1990) 25: 355-36011.       A preliminary clinical study of cyclophosphamide with reduced glutathione as uroprotector, Nobile, M.T.; Vidili, M.G.; Benasso, M.; Venturini, M.; Tedeschi, M.; Zunino, F.; Rosso, R.; Tumori, 75: 257-258, (1989)12.       Reduced glutathione and S-acethylglutathione as selective appoptosis-inducing agents in cancer therapy, Donnerstag, B.; Ohlenschläger, G.; Cinatl, J.; Amrani, M.; Hofmann, D.; Flindt, S.; Treusch, G.; Träger, L.; Elsevier, Cancer Letters 110 (1996) 63-7013.       Glutathione augments the activation of cytotoxic T-lymphocytes in vivo, Dröge, W.; Pottmeyer-Gerber, Ch.; Schmidt, H.; Nick, S.; Immunobiol., Vol. 172, pp. 151-156 (1986)14.       Studie über die Wirkung von GSH, L-Cystein und Anthocyanen (Recancostat® Comp.) bei metastatischem kolorektalem Karzinom mit relativer Mangelernährung, Garcia-Giralt, E.; Perdereau, B.; Brixy, F.; Rhilouch, H.; Treusch, G.; Ohlenschläger, G.; Pouillart, P.; Seventh International Congress on Anti-Cancer Treatment, 3.-6.02.199715.       Attestation, Perdereau, B.; Institut Curie, Section médicale et hospitaliére, 5.7.199916.       Refreshment effect of reduced glutathione, anthocyans and L-cystein on lymphocyte subsets and prevention of respiratory infections in chernobyl children, Chernyshov, V.; Omelchenko, L.; Treusch, G.; Vodyanik, M.; Vykhovanets, E.; Pochinok, T.; Institut of Pediatrics, Obstetrics and Gynecology, Academy of Medical Sciences, Kiev; 5th International Conference on the Prevention of Infection, May 6th-7th 1998 Acropolis Nice (France)17.       Disorders in mononuclear phagocytes and reduced glutathione and their correction in Chernobyl children with recurrent respiratory infections and chronic inflammatory focal lesions, Chernyshov, V.P.; Omelchenko, L.I.; Treusch, G.; Vodyanik, M.A.; Pochinok, T.V.; Zelinsky, G.M.; Gumenyuk, M.V.; Institut of Pediatrics, Obstetrics and Gynecology, Academy of Medical Sciences, Kiev; Elsevier, Immunology Letters, Vol. 73, No. 2,3 73 75-302, Abstract No. 523, Abstracts of the 14th European Immunology Meeting EFIS 2000, 23.-27.09.200018.       Immunological analysis of reduced glutathione, L-cystein and Anthocyane effects in Chernobyl children with recurrent respiratory infections and chronic inflammatory focal lesions, Chernyshov, V.P.; Omelchenko, L.I.; Treusch, G.; Vodyanik, M.A.; Pochinok, T.V.; Zelinsky, G.M.; Gumenyuk, M.V.; Institut of Pediatrics, Obstetrics and Gynecology, Academy of Medical Sciences, Kiev; Central European Journal of Immunology, Vol. 25, 3-200019.       Glutathion treatment of hepatocellular carcinoma, Dalhoff, K.; Ranek, L.; Mantoni, M.; Poulsen, H.E.; University of Copenhagen; Liver 1992: 12: 341-343, Munksgaard (1992)20.       Redox Recycling between Glutathione and Anthocyans in Vitro, Ohlenschläger, G.;Treusch, G.;21.       Suppression of Tumor Cell Growth by Anthocyanins in Vitro, Kamei, H.; Kojima, T.; Hasegawa, M.; Koide, T.; Umeda, T.; Yukawa, T.; Terabe, K.; Cancer Investigation, 13(6), 590-594 (1995), Marcel Dekker, Inc.22.       Flavonoide-Mediated Tumor Growth Suppression Demonstrated by in vivo Study, Kamei, H.; Tatsurou, K.; Kojimam, T.; Hasegawa, M.; Umeda, T.; Terabe, K.; Hashimoto, Y.; Cancer Biotherapy & Radiopharmaceuticals, Vol. 11, No. 3 (1996) Mary Ann Liebert, Inc.23.       Reduced glutathione and anthocyans – Redox-cycling and redox-recycling in bioloogical systems, Ohlenschläger, G.; Treusch, G.; Praxis-Telegramm, Special Edition, Supplement to issue No. 6/94, December 1994, Ralf Reglin Verlag, Köln24.       Lexikon der Biochemie und Molekularbiologie; Herder Verlag, Band 2, 1992

 

NEUROLOGIC DISORDERS ( ALZHEIMER’S, PARKINSON’S & MOTOR NEURON DEFECT) & GLUTATHIONE

PHASE II

Glutathione is a reservoir of cysteine (also of inorganic sulfate). Inorganic sulfate is activated by 2 ATP molecules, producing PAPS (phosphoadenosyl phosphosulfate) and this molecule reacts with exotoxins to produce sulfated derivates.

In patients with neurologic disorder such as Alzheimer’s disease, Parkinson’s disease, and motor neuron defect, it appears that the enzyme responsible for sulfation of cysteine to sulfate is often deficient, leading to an elevated plasma cysteïne/sulfate ratio.

Glutathion and MSM therapy -molybdenum is cofactor for sulfite oxidase (sulfation) ! molybdenum status (if too high sulfation is lowered).

  • Glutathione, oxidative stress and neurodegeneration. Schulz JB, Lindenau J, Seyfried J, Dichgans[J.Eur J Biochem 2000 Aug;267(16):4904-11]
  • Alterations in glutathione levels in Parkinson’s disease and other neurodegenerative disorders affecting basal ganglia. Sian J, Dexter DT, Lees AJ, Daniel S, Agid Y, Javoy-Agid F, Jenner P, Marsden CD [Ann Neurol, 36(3):348-55